Agilent Capillary

Coupling Liquid-Phase Separations with Mass Spectrometry

Since HPLC technology matured in the early 1980s, its coupling with mass spectrometry remained a challenge for some time. Bringing the analytes out of liquid phase into the gas phase, ionizing them, and transferring the molecular ions into ultrahigh vacuum, is far more difficult for liquid-phase separations (LC) than for gas-phase separations (GC). The field has seen multiple iterations in LC/MS interfacing methodology since the 1970s.

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Agilent Capillary Electrophoresis Complete system solution

Over many years, Agilent Technologies has been the only analytical equipment manufacturer offering a complete system solution for CE/MS.
The basis of the interfacing technology is the coaxial solvent sheath flow or triple tube CE/MS interface. This guidebook focuses on the use of this interface for CE/MS coupling
Capillary electrophoresis (CE) is a versatile technique that offers fast separations with exceptional efficiency and resolution.
Our range of innovative CE and capillary electrophoresis mass spectrometry (CE/MS) instrumentation offers a flexible and efficient alternative to LC for difficult analytical challenges.